The England international leads the line at St James' Park in the absence of Luis Suarez, who begins his 10-match ban for biting Branislav Ivanovic
Sturridge is preferred up front to Jonjo Shelvey and Fabio Borini, who only returned to full training this week after dislocating his shoulder against Swansea in February.
For the hosts, Rob Elliot continues in goal in the absence of Tim Krul, who has been ruled out for the the rest of the season with a dislocated shoulder.
Hatem Ben Arfa is the only other high-profile omission for the Toon as he continues his slow return to match fitness on the substitutes' bench.
Newcastle: Elliot; Debuchy, S Taylor, Yanga-Mbiwa, Haidara; Perch, Tiote, Cabaye; Sissoko, Cisse, Gutierrez.
Subs: Harper, Williamson, Gosling, Anita, Ben Arfa, Gouffran, Shola Ameobi.
Liverpool: Reina; Johnson, Carragher, Agger, Enrique; Lucas, Gerrard; Henderson, Coutinho, Downing; Sturridge.
Subs: Jones, Coates, Skrtel, Wisdom, Suso, Shelvey, Borini.