Emmanuel Adebayor is out, while midfielders Aaron Lennon and Lewis Holtby are on the substitutes' bench and both Tom Huddlestone and Kyle Naughton are back in the starting XI
Tom Huddlestone is also in the Spurs XI alongside Mousa Dembele and Scott Parker in midfield, while Clint Dempsey supports Defoe in attack.
Kyle Naughton replaces Benoit Assou-Ekotto at left-back, with the Cameroon international dropping to the bench.
Wigan manager Roberto Martinez makes two changes to the team that lost 2-0 to West Ham, with Antolin Alcaraz and Gary Caldwell replaced by Jean Beausejour and James McArthur.
Goalkeeper Joel continues in front of Ali Al-Habsi, while Arouna Kone, Callum McManaman and Shaun Maloney continue to spearhead the Latics' attack as they bid to avoid relegation, trailing Aston Villa by three points.
Wigan starting XI: Joel, Kone, McCarthy, Maloney, Gomez, McManaman, McArthur, Boyce, Beausejour, Figueroa, Scharner.
Subs: Al Habsi, Caldwell, Watson, Di Santo, Henriquez, Espinoza, Stam.
Tottenham starting XI: Lloris; Walker, Dawson, Vertonghen, Naughton; Dembele, Huddlestone, Parker; Dempsey, Defoe, Bale.
Subs: Friedel, Assou-Ekotto, Caulker, Carroll, Holtby, Lennon, Sigurdsson.