The Paraguay defender's return from a groin problem has coincided with the Latics' upturn in form in recent weeks, but he could be sidelined again after the defeat to West Ham
The Latics are already missing Ivan Ramis in defence after the Spaniard's campaign was ended by a knee injury and could now add Alcaraz to their list of absentees at the back.
|11/10||Wigan are 11/10 with BetVictor to avoid relegation from the Premier League
"The injury to Antolin made for a very difficult afternoon for us," the Wigan boss told reporters.
"He's got a soft tissue injury to the back of his hamstring, and so we'll assess him this week before discovering exactly how long he'll be out for.
"It's obviously a real negative note, and had an effect on how we wanted to play."
Wigan have lost only three of the nine games Alcaraz has featured in since his return from a six-month lay-off due a groin problem.