The Latics are already missing Ivan Ramis in defence after the Spaniard's campaign was ended by a knee injury and could now add Alcaraz to their list of absentees at the back.
|11/10||Wigan are 11/10 with BetVictor to avoid relegation from the Premier League
"The injury to Antolin made for a very difficult afternoon for us," the Wigan boss told reporters.
"He's got a soft tissue injury to the back of his hamstring, and so we'll assess him this week before discovering exactly how long he'll be out for.
"It's obviously a real negative note, and had an effect on how we wanted to play."
Wigan have lost only three of the nine games Alcaraz has featured in since his return from a six-month lay-off due a groin problem.