Steve Clarke's men travel to St Mary's Stadium to take on the Saints with both teams having enjoyed strong campaigns, and you could be there to watch the action
The seats for the clash at St Mary's Stadium will be located amongst the home support.
To be in with a chance of winning the tickets, simply send your answer to the following question along with your name, address and telephone number to email@example.com.
Against which team did Mauricio Pochettino celebrate his first victory as Southampton manager?
A) Manchester City
The competition will close at 11:00 GMT on Wednesday, April 24, and winners will be announced by Friday, April 26.
Don't worry if you're not successful - you can always win a pair of tickets by visiting your nearest Barclays ATM and requesting a receipt or by going online to www.barclaysticketoffice.com – you don't even have to be a Barclays customer.
Match tickets are up for grabs EVERY 90 minutes, every day, throughout the 2012-13 season.