The Englishman has been sidelined since sustaining knee ligament damage back early in the campaign, last appearing for the Eastlands side in their 1-0 over Swansea on October 27.
Elsewhere in Roberto Mancini's line-up, Vincent Kompany and Joleon Lescott partner in central, whilst Carlos Tevez is supported up front by want-away Samir Nasri and Sergio Aguero.
Manchester City: Hart, Richards, Kolarov, Lescott, Kompany, Barry, Garcia, Yaya Toure, Nasri, Aguero, Tevez
Subs: Pantilimon, Milner, Dzeko, Sinclair, Rodwell, Clichy, Toure, K
Wigan Athletic: Robles, Kone, Alcaraz, McCarthy, Di Santo, Maloney, Gomez, Boyce, Beausejour, Figueroa, Scharner
Subs: Al Habsi, Caldwell, Henriquez, McManaman, McArthur, Espinoza, Stam