The Welshman left the pitch on a stretcher after his right ankle buckled under an innocuous-looking challenge from David Degen, moments before the end of an enthralling Europa League quarter-final first leg which finished in a 2-2 draw.
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Bale is expected to miss the match against David Moyes' side, along with the return leg against Basel the following Thursday but the 23-year-old could make his comeback for visit of Premier League champions Manchester City on April 21.
Aaron Lennon who limped out of Spurs' draw against Basel with a knee problem is also expected to return to training within two weeks, along with William Gallas, who was forced off late on in the same match with a calf strain.