The 48-year-old believes his side stand little chance of overturning the current 15-point deficit between themselves and Sir Alex Ferguson's side at the top of the table
However, with an FA Cup semi-final still to contest against the winners of a replay between United and Chelsea, Mancini refused to be downbeat about their season, instead backing his side to cement second place in the league and finish the term strongly.
"It's over, but this doesn't change anything because we should do our best from now to the end," Mancini told reporters.
"Every top team, when you can't win a title, you should try to play well, try to win all the games, and we have the FA cup semi-final.
"We have Chelsea four points behind, Tottenham five points behind and we play another nine games. For this reason it's important to keep working hard."The future of the Italian boss remains up in the air, amid reports that he, along with midfielder Yaya Toure have been targeted by French outfit Monaco, but Mancini laughed off suggestions he was interested in the role.
He added: "Monaco is one of the best teams in the French Second Division and they have a good manager. I'll stay here for a long time, like Yaya."