Spurs surrendered an eight-point lead to local rivals Arsenal last term and are in danger of falling away again after defeats in their last two league games.
Holtby, however, says Spurs do not fear their north London foes and are well prepared going into the final stretch of games.
"No we’re not scared. That’s the past. We are prepared," he told the Daily Mail.
"We have a lot of players who have seen that but we are prepared now and we have to just focus on our game. We don’t look at the table, just win our games and at the end we can watch and hope that we are in the top four.
"We can definitely do it. We had 12 unbeaten league games, we had a very good run. And now we’ve had three disappointing games."
The former Schalke midfielder hopes the international break will have given his team-mates a chance to clear their heads and ready themselves for the run-in.
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"These 12 days of international break are really good for us to clear everybody’s head; to go to the national team and see something else. We will bounce back, especially in the next game," he continued.
"There are still a lot of games to play and I think we have the right mentality and the right quality to play Champions League next season."
Tottenham sit in fourth place, one point behind Chelsea and four ahead of Arsenal, having played one game more than their two London rivals.