Nikica Jelavic and Phil Neville drop down to the bench following their 3-0 defeat to Wigan at Goodison Park last weekend in the FA Cup, with Darron Gibson and Victor Anichebe starting for the Toffee's.
Manchester City make four changes to the side which defeated Barnsley in the FA Cup, with Joe Hart returning in goal at the expense of Costel Pantilimon.
Joleon Lescott fails to make the starting line-up to play against his former team, alongside Samir Nasri who also can only claim a position on the bench, making way for Matija Nastasic and James Milner.
Javi Garcia also returns to the line-up, after Yaya Toure was ruled out for the game with a migraine.
Everton: Mucha, Baines, Gibson, Heitinga, Mirallas, Distin, Osman, Pienaar, Coleman, Fellaini, Anichebe
Subs: Springthorpe, Oviedo, Jelavic, Naismith, Neville, Barkley, Duffy
Manchester City: Hart, Zabaleta, Kolo Toure, Nastasic, Milner, Garcia, Barry, Kolarov, Silva, Tevez, Dzeko
Subs: Pantilimon, Razak, Nasri, Sinclair, Lescott, Clichy, Lopes.