The Black Cats were overcome by the Rs, despite taking an early lead through Steven Fletcher, as goals from Loic Remy, Andros Townsend and Jermaine Jenas consigned them to defeat.
With consecutive home fixtures against Norwich City and Manchester United to come, O'Neill was eager to emphasise the magnitude of the games ahead.
"It's a tough old set of fixtures for us between now and the end of the season, we need to get some points on the board," he told reporters.
|UNLUCKY BLACK CATS|
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The 61-year-old also admitted that the clash at Loftus Road was always going to be a difficult one, although he felt that his side coped well, citing Townsend's stunning strike as a turning point in the tie.
"It was always going to be a difficult game for us," he continued.
"QPR were buoyed by their win over Southampton last week and we had to counteract that and deal with the swell of euphoria from the crowd, which I thought we did well.
"We put ourselves in front and it's a wonder goal from them to take the game to 2-1."