Tottenham: Lloris; Walker, Dawson, Caulker, Naughton; Dembele, Parker; Lennon, Holtby, Dempsey; Bale.
Subs: Friedel, Vertonghen, Gallas, Assou-Ekotto, Livermore, Sigurdsson, Adebayor.
Newcastle: Krul; Debuchy, S.Taylor, Coloccini, Santon; Gouffran, Cabaye, Perch, Gutierrez; Sissoko; Cisse.
Subs: Harper, Yanga-Mbiwa, Anita, Tiote, Marveaux, Obertan, Shola Ameobi.
Andre Villas-Boas makes three changes from the side which defeated West Brom 1-0 on Sunday, with Steven Caulker, Kyle Naughton and Lewis Holtby all joining the starting eleven.
Jan Vertonghen and Benoit Assou-Ekotto can only claim positions on the bench, with Villas-Boas undoubtedly keeping an eye on their midweek Europa League clash against Lyon.
Lewis Holtby makes his first start for home side, with Emmanuel Adebayor being named as a substitute following his late arrival back to the capital after the AFCON.
Newcastle name the same starting eleven which have won their previous two fixtures, although returning Cheick Tiote is named amongst the Newcastle substitutes.