Nigel Adkins' men are looking to boost their survival hopes, while David Moyes' charges aim for a Champions League spot and you have the chance to watch the match!Goal.com has teamed up with Barclays, title sponsor of the Premier League, to offer one lucky reader the opportunity to win a pair of tickets to Southampton v Everton on Monday January 21.
To be in with a chance of winning the tickets, simply send your answer to the following question along with your name, address and telephone number to email@example.com.
Who is Southamton's top scorer in the Premier League this season?
A) Rickie Lambert
B) Jason Puncheon
C) Gaston Ramirez
The competition will close at 10:00 GMT on Wednesday, January 16, and winners will be announced later in the week.
But don't worry if you're not successful - you can always win a pair of tickets by visiting your nearest Barclays ATM and requesting a receipt or by going online to www.barclaysticketoffice.com – you don't even have to be a Barclays customer.
Match tickets are up for grabs EVERY 90 minutes, every day, throughout the 2012-13 season.
Further information and terms and conditions are available from www.barclaysticketoffice.com.