Nigel Adkins' men are looking to boost their survival hopes, while David Moyes' charges aim for a Champions League spot and you have the chance to watch the match!
To be in with a chance of winning the tickets, simply send your answer to the following question along with your name, address and telephone number to email@example.com.
Who is Southamton's top scorer in the Premier League this season?
A) Rickie Lambert
B) Jason Puncheon
C) Gaston Ramirez
The competition will close at 10:00 GMT on Wednesday, January 16, and winners will be announced later in the week.
But don't worry if you're not successful - you can always win a pair of tickets by visiting your nearest Barclays ATM and requesting a receipt or by going online to www.barclaysticketoffice.com – you don't even have to be a Barclays customer.
Match tickets are up for grabs EVERY 90 minutes, every day, throughout the 2012-13 season.
Further information and terms and conditions are available from www.barclaysticketoffice.com.