The Gunners thrashed the Magpies 7-3 last weekend, and the French boss has opted to continue with hat-trick hero Theo Walcott, Lukas Podolski and Alex Oxlade-Chamberlain
The England international bagged a hat-trick in last weekend's 7-3 win at home to Newcastle, with Lukas Podolski and Alex Oxlade-Chamberlain, who both scored against the Magpies, also retaining their places in the XI.
Subsequently, Olivier Giroud must settle for a place amongst the substitutes once again despite his double in the same fixture, with Gervinho and Tomas Rosicky also available from the bench.
For the hosts, manager Nigel Adkins makes four changes, with Gaston Ramirez returning to the side following Saturday's 3-3 draw away to Stoke.
Southampton starting XI: Boruc; Cork, Fonte (c), Yoshida, Shaw; Puncheon, Schneiderlin, S. Davis, Guly, Ramírez; Lambert
Subs: K. Davis, Hooiveld, Rodriguez, Ward-Prowse, Richardson, Mayuka, De Ridder
Arsenal starting XI: Szczesny; Sagna, Vermaelen, Koscielny, Gibbs; Arteta, Wilshere, Oxlade-Chamberlain; Cazorla, Podolski, Walcott
Subs: Martinez, Mertesacker, Coquelin, Ramsey, Rosicky, Gervinho, Giroud