Kolo Toure replaces Vincent Kompany as Mancini makes two changes from last weekend's derby, whereas Pardew makes one change, James Perch starting in place of Hatem Ben Arfa
The midfielder was a doubt with migraine but is fit enough to make Roberto Mancini's starting line-up.
Mario Balotelli is dropped from the Manchester City squad altogether as Mancini hands Carlos Tevez a starting berth, after the Argentine impressed as a second half substitute against Manchester United.
The Champions are also without their skipper Vincent Kompany; the Belgian sits out with a groin injury with Kolo Toure starting in his place.
Meanwhile for Newcastle, Alan Pardew is without influential midfielder Hatem Ben Arfa, who is struggling with a groin problem, so James Perch takes his position in the Magpies' first XI.
Newcastle: Krul; Simpson, Williamson, Coloccini, Santon; Perch, Tiote, Anita; Cisse, Ba, Gutierrez.
Subs: Elliot, Tavernier, Ferguson, Bigirimana, Marveaux, Sammy Ameobi, Shola Ameobi.
Manchester City: Hart; Zabaleta, Kolo Toure, Nastasic, Clichy; Garcia, Yaya Toure, Nasri, Silva, Tevez; Aguero.
Subs: Pantilimon, Razak, Rekik, Sinclair, Dzeko, Kolarov, Lescott.