The Royals took the lead twice but eventually were beaten by a single goal, with all strikes netted in a frantic first half at the Madejski Stadium.
The striker scored Reading's second goal after 19 minutes, equalising with a header from a corner, and the home side went 3-2 up through Sean Morrison minutes later, only to concede two more goals before the break.
Le Fondre told The Sun: "Scoring against United was something I dreamt of as a kid but ultimately it's a results business.
|15/8||Reading are 15/8 with Bet365 to finish bottom of the Premier League|
The Berkshire side remain second from bottom after the defeat but the 26-year-old believes that the team can draw confidence from the performance, commenting: "We had a top team on the ropes.
"If we play like we did today, and tighten up a bit defensively, we have a real chance of going to Southampton and Sunderland and getting the right results."