The pair will miss the Latics’ clash with Manchester City on Wednesday after picking up injuries during their side's 3-2 victory over Reading on Saturday
Antolin Alcaraz (groin), Albert Crusat (knee) and captain Gary Caldwell (hamstring) are all already out of action, alongside Ryo Miyaichi (ankle) and Ben Watson (leg).
|PREMIER LEAGUE LATEST
|20/1||Man City are 20/1 with Bet365 to beat Wigan 4-0
Maloney picked up a groin injury, whilst Ramis suffered a hamstring problem. And Martinez insisted that the former’s injury was the worst of the two.
"Shaun's injury is worse than Ivan's,” Martinez told reporters.
“He has picked up a groin strain and, although we'll assess him, it looks as though he'll be out for a while.
"With Ivan's injury, we managed to catch it just in time before it got worse. He felt a twinge in his hamstring and we'll assess him to see how long he'll be out for."
One consolation for the Spaniard will be the return of James McArthur, who made an appearance as a late substitute against Reading on Saturday after four weeks out of action.