The centre-back played in a 4-1 League Cup defeat to the Gunners two years ago, but beat them 3-2 when on loan at Swansea last year and is looking for a similar showing on Saturday
The centre-back played 90 minutes of the heavy loss at White Hart Lane in a third-round League Cup tie in 2010.
And Caulker, who scored his first goal for England in midweek, is relishing his first ever Premier League north London derby after stepping up to the Tottenham first team this season.
"It will be very surreal knowing that in the space of two years I will be playing them again in a Tottenham shirt in a league game," he told Spurs TV Online.
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He said: "That's what I have always wanted to do. Last year I beat Arsenal 3-2 when I was at Swansea. That was obviously a great moment and I hope we can do the same at the weekend.
"Going on loan has been crucial for me, especially the season at Swansea. We played in such a way that it improved my composure on the ball and it helped me learn how to play it out from the back."