Goal.com exclusively revealed earlier on Thursday that the midfielder, who had been sidelined for over a year with ankle problems before finally returning in October, has agreed to only play the opening 45 minutes of Wednesday's clash.
Wilshere completed his first 90 minutes since making his comeback in a 2-2 draw against Schalke in the Champions League and was included in the England squad by Hodgson as he will miss Saturday's visit of Fulham when he serves his one-match suspension, though Wenger revealed that he was against the idea of the midfielder going on international duty.
"You know what I think with Jack, that it is early for him," the Frenchman told reporters.
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"He will have a little breather. Roy wants him in the group to connect the game with the players. The ideal solution would be [that he wouldn't be involved]. But it is as it is.
"Jack has played three games now and, of the three games, only one full game. He has been out for 17 months.
"It is good to have a little break after three games. What we like of him is he won't play over the weekend, so will recover. I think he needs 10 days of good recovery."
Arsenal right-back Carl Jenkinson is also set to be drafted into the squad. The 20-year-old defender has been in good form covering for the injured Bacary Sagna and Wenger is delighted that his performances have been rewarded.
"I am happy that his potential has been acknowledged by Roy Hodgson, so that is good news," the Gunners boss added.
"Carl is a guy with massive potential and I believe the positive of that is it will improve his belief, and that is very important for him in my opinion."