The Senegalese hit man returns to the starting line up after netting the winner in the Magpies' last outing, while Steven Gerrard gears up for his 600th game in a Reds jersey
Brad Jones continues in goal for the Reds, while Brendan Rodgers also decides to stick with youngsters Andre Wisdom, Raheem Sterling and Suso.
Meanwhile, captain and talisman Steven Gerrard will make his 600th appearance for the club during the clash, alongside Luis Suarez who remains up front.
As for the Magpies, Alan Pardew makes three changes from the side that started the 2-1 victory over West Brom last time out as the north East outfit look to put straight a poor away record against the Merseyside outfit.
Match-winner Papiss Cisse replaces Shola Ameobi to partner Demba Ba up front, with Vurnon Anita and Steven Taylor coming in for Mike Williamson and Danny Simpson in defence.
Elsewhere, Hatem Ben Arfa will look to threaten from midfield while the likes of Yohan Cabaye and Fabricio Coloccini will try and stop Gerrard from making it a memorable milestone.
Liverpool starting XI: Jones, Wisdom, Enrique, Agger, Skrtel, Sahin, Gerrard, Allen, Suso, Sterling, Suarez
Subs: Gulacsi, Henderson, Assaidi, Carragher, Shelvey, Downing, Coates
Newcastle starting XI: Krul; Anita, S.Taylor, Coloccini (c), Santon; Ben Arfa, Perch, Cabaye, Gutierrez; Ba, Cisse
Subs: Harper, Williamson, Ferguson, Bigirimana, Obertan, Sammy Ameobi, Shola Ameobi