The Spurs striker features up front as manager Villas-Boas keeps the same team that beat Southampton while the Latics start with goalscorers Maloney and Beausejour
Jermain Defoe, Aaron Lennon and Sandro return to the squad after missing the 2-1 defeat to Norwich in the Capital One cup as the team return to Premier League action.
Roberto Martinez also saw his side score two as they won 2-1 against West Ham and has put faith in goalscorers Shaun Maloney and Jean Beausejour to conjure up more opportunities as he makes eight changes to the team that were knocked out of the Capital One Cup by Bradford.
Tottenham starting XI: Friedel; Walker, Caulker, Gallas, Vertonghen; Lennon, Sandro, Huddlestone, Bale; Dempsey, Defoe
Subs: Lloris, Dawson, Naughton, Carroll, Falque, Sigurdsson, Adebayor
Wigan starting XI: Al Habsi; Caldwell, Boyce, Ramis, Figueroa,;McCarthy, Watson, Beausejour; Kone, Di Santo, Maloney
Subs: Pollitt, Stam, Lopez, Jones, Gomez, McManaman, Boselli