Both sides are unchanged from last weekend as Manchester United aim to go top of the Premier League and the Gunners seek revenge for their 8-2 defeat in this fixture last season
The Dutchman leads Manchester United's attack against the side he captained to a 8-2 defeat at Old Trafford last season.
Ashley Young and Antonio Valencia keep their place on the flanks as Sir Alex Ferguson names an unchanged side from last week's win at Stamford Bridge.
Theo Walcott only starts on the bench despite his midweek hat-trick in the Capital One Cup.
Jack Wilshere does the make starting line-up after making his comeback from injury against QPR last weekend.
Keiran Gibbs and Wojciech Szczesny remain sidelined, with Vito Mannone and Andre Santos keeping their place in Arsene Wenger's side.
Manchester United starting XI: De Gea; Rafael, Ferdinand, Evans, Evra; Valencia, Carrick, Cleverley, Young; Rooney, Van Persie.
Subs: Lindegaard, Anderson, Chicharito, Nani, Scholes, Powell, Wootton.
Arsenal starting XI: Mannone; Sagna, Santos, Mertesacker, Vermaelen; Arteta, Wilshere, Ramsey; Cazorla, Podolski, Giroud.
Subs: Martinez, Koscielny, Walcott, Coquelin, Arshavin, Jenkinson, Chamakh.