The 23-year-old has been drafted into the squad by coach Alejandro Sabella ahead of a friendly clash with Saudi Arabia on November 14 in Riyadh.
And Di Santo has hailed the honour, revealing his excitement at linking up with the likes of Lionel Messi, Gonzalo Higuain and Carlos Tevez.
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“There are many world class players right through the squad and of course it is a national team with a great history so to be given the chance to show the national team manager what I can do is a big honour for me and for my family.
“I’ve been playing with a lot of confidence lately and really enjoying my football so I’m delighted Alejandro has seen this and decided to give me a chance, I won’t let him, my country or my club down in doing so.”
Roberto Martinez is equally delighted for Di Santo and feels his call-up is a massive achievement both the striker and his club.
“Everyone at the club is extremely proud of his achievement," he said.
"To be called up alongside names such as Lionel Messi and Gonzalo Higuain in the Argentina forward line is an achievement in itself and I believe he has the potential to play in those positions with those players.
“He arrived at Wigan Athletic as a very young man and it’s been an incredible journey for him becoming a special footballer and a man.
“He’s now achieved something he’s always set his sights on and the next step for him is to achieve continuity within that squad and make sure he can gather as many caps as possible and compete in major tournaments.
“To have a striker in that squad from Wigan Athletic is a compliment to us as a team, but we want Franco to continue his development with this landmark; he’s only 23 remember with his best years ahead and that huge potential is there to be achieved.”