The 34-year-old lasted just 15 minutes of the 2-1 defeat on Tuesday night, with Roberto Di Matteo confirming a recurrence of a calf injury, and will now have a scan ahead of Sunday
|SHAKHTAR STARS WHO STUNNED CHELSEA
|8/1||Chelsea are 8/1 with William Hill to beat Manchester United 2-1 on Sunday
The 34-year-old lasted only 15 minutes of the 2-1 defeat before succumbing to a recurring calf problem that ruled the England international out of the San Marino and Poland games earlier in October.
Boss Roberto Di Matteo will now be sweating on the fitness of his vice-captain for the clash with the Red Devils as club captain John Terry serves the second of his four-game domestic ban.
"It's basically a recurrence of an old injury,” Di Matteo told reporters.
"He was training with us fine and there were no alarm bells before the game. He was in good condition to play."
However, Di Matteo is not expecting Chelsea's defeat in Donetsk to have a detrimental effect on his pre-match preparations, despite the loss leaving the holders' hopes of qualifying for the knockout stages hanging in the balance.
He added: "It's a team that has always shown the character after a defeat and I don't think the previous years should affect the way we are playing this season or where we are this year.
"We are doing everything we can to prevent that as well. The team is in good physical condition and also we have a good squad, so we'll try to utilise everybody that we can."