The Reds keeper fails to regain fitness for the Anfield outfit as Brian McDermott's side search for their elusive first win in the Premier League this season
Brad Jones replaces the Spaniard between the sticks and Fabio Borini misses out as he begins a lengthy spell out of action with a broken foot with youngster Suso taking his place in the starting line-up.
Left-back Luis Enrique has to make do with a place on the bench as does Jonjo Shelvey, who returns from suspension after making his first appearance for England in midweek.
Noel Hunt misses out for Brian McDermott's side but the Royals welcome Mikele Leigerwood back whileDanny Guthrie also starts.
Jason Roberts is named among the substitutes alongside Adam Le Fondre.
Liverpool: Jones, Wisdom, Johnson, Agger, Skrtel, Sahin, Gerrard, Allen, Sterling, Suso, Suarez.
Subs: Gulacsi, Shelvey, Henderson, Downing, Assaidi, Carragher, Enrique.
Reading: McCarthy; Cummings, Gorkss, Mariappa, Shorey; Kebe, Karacan, Leigertwood, McAnuff; Guthrie; Pogrebnyak
Subs: Subs: Taylor, Gunter, Pearce, McCleary, Robson-Kanu, Le Fondre, Roberts