The England forward believes his boss' attention to detail ahead of each game is hugely beneficial and reveals the squad are confident of their roles in each game.
Spurs host Villas-Boas' former club Chelsea on Saturday with the Blues currently four points clear at the top of the Premier League.
"What I like about him is every game has a different approach," he told The Sun.
"You know exactly how we’ve got to play when we’ve got the ball and not got the ball.
"Every player knows their jobs and if you speak to any of the boys, he has been fantastic."
Defoe is also hopeful that he won't be feeling the effects of his performance against Poland on a sodden pitch in Warsaw on Wednesday afternoon.
"It was quite heavy out there on your legs but hopefully I’ll feel all right at the weekend," he added.
"They are tough opponents and it was always going to be a difficult game even if the pitch was good.
"I don’t want to make excuses because both teams had to play on the pitch and maybe it was a fair result in the end."