Roberto Mancini's men are nothing short of formidable at the Etihad Stadium, where they have won 29 and lost none of their last 31 Premier League home matches.
This record makes hosts clear favourites at 3/4 (1.75) with Paddy Power to banish memories of the Real Madrid match with a victory here.
Arsenal have started the season strongly though, and with just one defeat in their last 10 Premier League away games, they may feel confident of getting a result.
Arsene Wenger's men are available at 4/1 (5.00) to end City's long unbeaten run by winning in Manchester, as they did 3-0 in this tie two years ago.
These two teams have not shared the spoils in their last four games in all competitions, but you can get odds of 5/2 (3.50) on a draw taking place in this one.
Although Manchester City fans have enjoyed some high-scoring games so far this season, they may not be so lucky in this fixture.
Only six goals have been scored in the last six meetings between these sides, as all three encounters last season ended 1-0.
Arsenal's defence appears reinforced by the coaching of legendary centre back Steve Bould, and City will be hard pressed to breach a backline against whom they have managed just one goal in the last five Premier League games.
With the visitors already recording two 0-0 draws this season, a low-scoring encounter seems to be on the cards, and odds of 11/10 (2.10) provide great value in the under 2.5 goals market.
Robin Van Persie's defection to Manchester United overshadowed an excellent summer of recruitment on Arsene Wenger's part, as the Frenchman's additions of Lukas Podolski and Santi Cazorla are already linking up to great effect.
With David Silva at his disposal, Roberto Mancini will know a Spanish midfield maestro when he sees one, and should be wary of the threat Cazorla poses.
The former Villareal man is already off the mark after scoring in the last away game at Liverpool, and is well worth backing at 4/1 (5.00) to find the back of the net on Sunday.
|Under 2.5 goals at 11/10 (2.10) with Paddy Power
||Santi Cazorla to score anytime at 4/1 (5.00) with Paddy Power
Sign up with Paddy Power for up to £250 in free bets and back Al's selections for this game
Al Hain-Cole is a Liverpool fan, experienced tipster and avid follower of European football. He specialises in accumulators and if you would like to read more from Al you can follow him on Twitter here.
Follow GoalBetting on