The Dutch left-back started his first game for the Red Devils against Wigan, and repaid Sir Alex Ferguson's faith by providing an assist before scoring a goal
In his first start for the Old Trafford club following his move from Vitesse Arnhem, the 23-year-old Dutchman provided an assist for Javier Hernandez before netting himself in impressive fashion.
As a result, 39.24% think that the defender will be the player to light up the Premier League, with many suggesting Patrice Evra's place in the starting XI may already be under threat.
Having scored two goals in his first start for new club Fulham, former United man Dimitar Berbatov is the player closest to Buttner in the voting with 32.47%.
Meanwhile, on the other side of Manchester, Javi Garcia, who scored a headed equaliser for his new club against Stoke over the weekend, gained 13.14% of the vote.
Not far behind, with 13.11% of readers backing him to make the biggest impact in the English top flight, comes former Crewe starlet and Manchester United midfielder Nick Powell, who also scored on his debut.
However, one player barely tipped to impact is Aston Villa's Matthew Lowton, with only 2.04% of readers convinced despite his a stunning goal against Swansea at the weekend.