Lukas Podolski fills the centre-forward role for the Gunners, who are unbeaten in 17 home games against Saints, while goalkeeper Wojciech Szczesny takes his place between the posts back from Vito Mannone after recovering from injury.
Theo Walcott is also among the Arsenal substitutes, but midfielder Abou Diaby misses out after picking up a hip injury while on international duty for France.
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Nigel Adkins has named the same starting XI which lost 3-2 at home to Manchester United, with the trio of new signings Gaston Ramirez, Emmanuel Mayuka and Maya Yoshida, amongst the substitutes.
Saints are pointless so far this season, while the Gunners are looking for their fourth straight Premier League clean sheet.
Arsenal: Szczesny; Jenkinson, Mertesacker, Vermaelen, Gibbs; Coquelin, Arteta, Cazorla; Oxlade-Chamberlain, Gervinho, Podolski.
Subs: Koscielny, Santos, Giroud, Walcott, Ramsey, Arshavin, Mannone.
Southampton: K. Davis, Clyne, Fonte, Hooiveld, Fox; Ward-Prowse, Schneiderlin, S. Davis, Puncheon; Lambert, Lallana.
Subs: Gazzaniga (GK), Yoshida, Rodriguez, Ramírez, Richardson, Mayuka, Chaplow.