The Netherlands international was withdrawn at half-time against Hungary on Tuesday, while Kagawa sat out Japan's qualifier with a back problem.
Alexander Buttner, another summer addition, makes his debut at left-back, while Darren Fletcher, who returned to the squad after 10 months out, fails to make 18-man squad.
|15/2||Manchester United are 15/2 to beat Galatasaray 3-0 in the Champions League with Paddy Power|
For Wigan, Roberto Martinez names the same starting XI and substitutes which earned a point in the 2-2 draw against Stoke City last time out.
Manchester United: Lindegaard; Rafael, Ferdinand, Vidic, Buttner; Nani, Carrick, Scholes, Giggs; Chicharito, Welbeck.
Subs: De Gea, Evans, Valencia, Van Persie, Cleverley, Powell, Kagawa.
Wigan: Al Habsi; Caldwell, Ramis, Figueroa; Boyce, McCarthy, McArthur, Beausejour; Maloney, Di Santo, Kone.
Subs: Pollitt, Watson, Crusat, Jones, Gomez, Boselli, Miyaichi.