Alexander Buttner, another summer addition, makes his debut at left-back for the Red Devils while Roberto Martinez names the same starting XI who drew 2-2 with Stoke CityRobin van Persie and Shinji Kagawa have only made the substitutes' bench for Manchester United after picking up injuries while on international duty.
The Netherlands international was withdrawn at half-time against Hungary on Tuesday, while Kagawa sat out Japan's qualifier with a back problem.
Alexander Buttner, another summer addition, makes his debut at left-back, while Darren Fletcher, who returned to the squad after 10 months out, fails to make 18-man squad.
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For Wigan, Roberto Martinez names the same starting XI and substitutes which earned a point in the 2-2 draw against Stoke City last time out.
Manchester United: Lindegaard; Rafael, Ferdinand, Vidic, Buttner; Nani, Carrick, Scholes, Giggs; Chicharito, Welbeck.
Subs: De Gea, Evans, Valencia, Van Persie, Cleverley, Powell, Kagawa.
Wigan: Al Habsi; Caldwell, Ramis, Figueroa; Boyce, McCarthy, McArthur, Beausejour; Maloney, Di Santo, Kone.
Subs: Pollitt, Watson, Crusat, Jones, Gomez, Boselli, Miyaichi.