Brazilian international Maicon will play in the absence of Pablo Zabaleta and Micah Richards whilst Sinclair makes a surprise start, keeping David Silva out of the starting XI.
Former Benfica man Garcia, who City signed for more than £15million on transfer deadline day, replaces ex-Everton midfielder Jack Rodwell in the side.
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Sergio Aguero is not in the squad, despite rumours that he was set to be included in Mancini's line-up.
For the hosts, new signing Michael Owen starts on the bench, with Peter Crouch playing a lone role up front, with support coming from Jonathan Walters and Michael Kightly in the wide positions.
Charlie Adam and Steven N'Zonzi make full debut's for the Potters.
Stoke City: Begovic; Wilkinson, Shawcross, Huth, Wilson; Walters, Whelan, N'Zonzi, Adam, Kightly; Crouch.
Subs: Sorensen, Cameron, Owen, Whitehead, Upson, Etherington, Jerome
Manchester City: Hart; Maicon, Kompany, Lescott, Clichy; Garcia, Y.Toure; Nasri, Tevez, Sinclair; Balotelli.
Subs: Wright, Dzeko, Kolarov, Rodwell, Barry, Silva, K.Toure.