The Bosnian striker replaces Mario Balotelli up top following the Premier League champions' draw with Liverpool at Anfield as the Rs' latest acquisition makes his bow
There is no start, however, for £6.2 million acquisition Scott Sinclair, who takes a place on the bench following his move from Swansea City on Friday.
Roberto Mancini is still without Sergio Aguero, Gareth Barry and Micah Richards, who are all currently sidelined with injury.
QPR boss Mark Hughes has handed an immediate debut to new arrival Esteban Granero, whilst Rob Green keeps his place between the sticks despite the Julio Cesar signing from Inter.
Manchester City starting XI: Hart; Zabaleta, Kompany, Lescott, Kolarov; Yaya, Rodwell; Silva, Nasri; Tevez, Dzeko.
Subs: Pantilimon, Clichy, Kolo, Milner, Sinclair, Razak, Balotelli.
QPR starting XI: Green; Bosingwa, Nelsen, Ferdinand, Fabio; Wright-Phillips, Park, Granero, Faurlin; Zamora, Johnson
Subs: Murphy, Derry, Cisse, Mackie, Onuoha, Dyer, Hoilett.