Jan Vertonghen will make his Tottenham debut against West Brom, while Emmanuel Adebayor returns to Spurs on the bench.
The Belgian moved to White Hart Lane from Ajax this summer and replaces Michael Dawson in Andre Villas-Boas' line-up as the England man looks set for a move from the club.
The Togolese striker completed his permanent return to the north London club this week but Jermain Defoe retains his starting place after netting in Spurs' season-opening defeat at Newcastle last week.
Rafael van der Vaart also comes into the Spurs line-up in place of Gylfi Sigurdsson.
Graham Dorrans returns to West Brom's starting line-up in place of Zoltan Gera. The Scottish midfielder missed last week's win over Liverpool to tend to his daughter who had contracted meningitis.
The Baggies remain unchanged at the back after shutting out the Reds, and will hope for another strong showing against Spurs' potent attack.
Totteham XI: Friedel; Walker, Vertonghen, Gallas, Assou-Ekotto; Sandro, Livermore; Lennon, Van der Vaart, Bale; Defoe.
Subs: Cudicini, Caulker, Naughton, Sigurdsson, Jenas, Townsend, Adebayor.
West Brom XI: Foster; Reid, McAuley, Olsson, Ridgewell; Mulumbu, Yacob; Morrison; Fortune, Long, Dorrans.
Subs: Myhill, Brunt, Rosenberg, Jones, Gera, Dawson, Lukaku.