The Red Devils had not lost an opening game since 2004 but were outmuscled by a brilliant Toffees side at Goodison Park on Monday.
And, despite the Scot hailing the Cottagers' recent improvement, he has called for his squad to make a statement with their first fixture at Old Trafford.
|25/1||Manchester United are 25/1 to beat Fulham 5-0 with Bet365|
"It's a football club that's grown tremendously since Roy [Hodgson] got them to the  Europa League final.
"The place is buzzing with a full house every week and there's a good atmosphere around the place.
"They have a lot of experience in their team. It won't be an easy game, but we're at home and we need to make an impact quickly after losing on Monday night, and we expect that."
United already find themselves three points behind rivals Manchester City, who are beginning their defence of the Premier League title.