The Blues' manager has concerns over the fitness of his midfielder after the 24-year-old represented Spain at both Euro 2012 and the Olympic Games during the summer
The Italian boss admitted that he will be forced to give Mata a break during the early part of the season to ensure he doesn't run the risk of being worn out following his exertions for Spain at both Euro 2012 and the Olympic Games.
Di Matteo will be one of many Premier League managers who will struggle to put out their first choice sides during the opening weekend following the two summer tournaments.
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Di Matteo has targeted the international fixtures during September as the time to give Mata a break.
"Mata needs a break because we run the risk of wearing him out, absolutely," Di Matteo told The Guardian.
"He's OK at the moment but it's important that you have a rest. We'll plan it intelligently so that he won't be missing too much of our season. There's been dialogue with Spain and there's been some joy. You need to look after the welfare of the player."Chelsea have spent big this summer and Di Matteo explained the signings of Marko Marin, Eden Hazard and Oscar were made to ease the goalscoring burden on Fernando Torres and Daniel Sturridge.
"We've signed some very good players and I'm sure they will score goals for us. They have come to a big club, the expectations are high and the pressure will be on for everybody," he said.
"In certain areas we are a bit light, in the attacking areas ... but the two strikers we've got are very good," Di Matteo said.
"They can score goals and I'm sure they will. And we need the other players to chip in, Mata, Hazard, Oscar, [Frank] Lampard always scores goals and Ramires."