The Belgium international has been linked with Italian giants AC Milan as well as Manchester United after impressing in his first season in Lisbon following a €7m (£5.4m) transfer from Standard Liege last summer.
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Earlier in the month, Benfica sporting director Rui Costa stated that no offer had arrived for Witsel, and the club's president has now intimated that he plans to honour the €40m figure included in the player's release clause.
"Every club knows what his release clause is," Vieira told Antena 1. "If they come here and pay that fee, then there is nothing that we can do.
"We are very happy with Witsel and we do not think about selling him."
Witsel, 23, made 29 league appearances for Benfica in 2011-12, scoring one goal in the process.