The Hoops are set for a busy summer of transfers as the boss admits a number of players are set to leave the club, even if they get relegated to the Championship
The club's owner, Tony Fernandes, has committed his future to the club meaning there is likely to be funds available for the manager to spend.
Hughes told The Fulham Chronicle: "Every club will look at their current staff and what they need to build and get stronger.
"And that won't change no matter what club I'm at. We're looking to make it stronger and that means a number of players will go as a result."
The Rs travel to Manchester City on Sunday needing a point to guarantee their top-flight status, but they could stay up in defeat if Bolton fail to beat Stoke.
Players that are most likely to leave include Radek Cerny, Fitz Hall, and Kieron Dyer among others who are all out of contract at the end of the season and have failed to make any significant impact on the starting XI this season.
QPR will also try to offload fringe players such as Matt Connolly, Brian Murphy, Angelo Balanta, Troy Hewitt, and Rob Hulse.
The Hoops may be keen to keep Adel Taarabt at Loftus Road, with the Moroccan finding form since Hughes' arrival in January.