The former Wales boss believes his side will give it their "best shot" as they face the league leaders in their final game of the season with safety still in their hands
The Welshman is hoping to be the first manager to beat his former club at the Etihad Stadium this season, though Roberto Mancini's men can seal the league title with a win.
Hughes told Sky Sports: "We haven't covered ourselves in glory this year on the road, but what better time to turn it around?
"There will be a huge amount of expectation on the game with them going for the title, but we'll give it our best shot.
"It's unbelievable what this league throws up time and again, but it's in our hands and that's all we can ask for."
Hughes admitted that the task ahead is an unenviable one but says his side must simply give a better performance than the one which saw them beaten 6-1 by west London rivals Chelsea last weekend.
"Obviously results elsewhere could help us out, but we want to go and make it happen ourselves," he continued,
"My focus is totally on what we do - I get the feeling we'll be a lot better than we were at Chelsea last week."