The Belgium international had been rested for his side's draw with Bolton last weekend but produced some fine stops as the Mackems lost out to Martin Jol's men
The Belgian had been replaced by Craig Gordon last weekend as the Mackems drew 2-2 with Bolton but marked his comeback with some fine work between the sticks even in defeat.
"I was very pleased to come back in," Mignolet told the club's official website.
"There's huge competition and we have three very good goalkeepers here.
"I'm happy the manager chose me again after Craig [Gordon] put in a good performance last week.
"Of course I am pleased to play again but on the other hand it is disappointing to have lost the game."
Mignolet was beaten by a Clint Dempsey free-kick before a deflected effort from compatriot Moussa Dembele settled the game in the home side's favour after Phil Bardsley had equalised.
And whilst the Mackems had chances to pinch a point, most notably through Fraizer Campbell, Mignolet says his side know they need to take their chances away from home.
"Obviously conceding the free-kick made it tough but we came back with a great goal," he added.
"But we conceded so early after equalising, which made things difficult for us.
"I thought we played well in the second half and created some opportunities, but you have to take one or two.
"Fulham are a good side and it's a tough place to come. Unfortunately we didn't manage to take our chances."