Sir Alex Ferguson's men lead City by three points at the top of the table, but know defeat to Roberto Mancini’s side will see them surrender top spot.
Giggs admitted the game is one of the biggest he’s ever played in his 22-year career but believes he and his team-mates are ready for the challenge.
The Welshman told reporters: "City will be looking at it and fancying themselves to win the game, just like ourselves, because they're a good team and they're at home,
"But we're Man United, we're the champions and we'll try to go out there and put a statement out that we deserve to win this league.
“It's a bit frustrating [that points have been dropped in recent weeks] but there's nothing we can do about it now. It's still in our hands and if we win we'll be in a brilliant position. It could have been better but it's not and we realise that.
|15/2||Ryan Giggs is 15/2 with Paddy Power to score at any time in Monday's Manchester derby.|
"There is no mistaking that this is a massive game and the biggest in recent times. We realise it's a big game but as a player you're used to it and, as a United player, we're definitely used to it.
“You've got to block out the hype and what's being said and predictions – that's been going on all the way through the season. We just have to make sure we're ready.”
Giggs also acknowledged that his side had been fortunate to keep in touch with City earlier in the season but now feels that the Red Devils' superior experience will begin to tell.
He added: "City are a good side. They were on fire pre-Christmas and we were just trying to hang on, really.
“We managed to do that and we've come into form in the second half of the season. It's come down to this now – we're neck and neck and it's about whoever puts in the performance on Monday.
"We have got that experience when it comes to winning titles but City have got experienced players who have maybe won titles with other clubs. We just need to make sure we use the experience we've got and make sure it works for us."
Giggs believes the Red Devils must go to the Etihad Stadium with the desire to win all three points but also feels they must play to the situation of the game.
“We've got to go out there to try and win," Giggs said. "Obviously, if there's a few minutes to go and it's all square we won't be pushing six or seven players forward and we'll probably try to get the draw.
“But really we've got to go to try and win it because if we just try to defend against a very good team we might come unstuck. So we'll go for it and try to win but obviously the scenarios are more in our favour than City.”
The 38-year-old went on to insist that poor results, such as the recent loss to Wigan and draw against Everton, has given United a warning that nothing but their best will suffice if they want to secure the club's 20th top-flight title.
"We've had reminders throughout the season where we've lost games or put in poor performances and we've always reacted. Hopefully that's the case this time after the disappointment against Everton.
"We've reacted well all season and that's one of the reasons we're still up there. We've got good memories of the last time we played at their place [in the FA Cup]. We'll take the experience we got from that game into this one."