After scoring a late goal against Barcelona in midweek, the Spaniard earns a starting spot while Kalou and Sturridge also come in up front and Cisse returns for the Hoops
Chelsea make six changes from the side that triumphed over Barca on Tuesday, with Paulo Ferreira and Jose Bosingwa replacing the suspended Branislav Ivanovic and injured Gary Cahill in defence.
Frank Lampard and Juan Mata retain their places in the midfield with Michael Essien being preferred to the dropped John Obi Mikel.
Didier Drogba, Ramires and Raul Meireles all drop down to the bench after their midweek efforts, with Daniel Sturridge, Salomon Kalou and Fernando Torres forming a front three.
QPR boss Mark Hughes makes two changes to the side that beat Tottenham 1-0 last weekend, keeping the same back four and keeper in Paddy Kenny.
Akos Buzsaky replaces Samba Diakite in midfield alongside Joey Barton and Shaun Derry, while Djibril Cisse returns to fill the void left by the suspended Adel Taarabt.
Chelsea: Cech; Ferreira, Bosingwa, Terry, Cole; Essien, Lampard; Sturridge, Mata, Kalou; Torres.
Subs: Turnbull, Hutchinson, Romeu, Ramires, Meireles, Malouda, Drogba.
QPR: Kenny; Onuoha, Ferdinand, Hill, Taiwo; Barton, Derry, Buzsaky, Mackie; Cisse, Zamora.
Subs: Cerny, Gabbidon, Campbell, Traore, Young, Smith, Wright-Philips.