After becoming the first team since Southampton in 2001 to beat Manchester United and Arsenal in consecutive Premier League matches, the Latics are now on 34 points, five clear of the drop-zone.
And the striker believes a further three points away against Fulham will do wonders in their ever-improving bid to secure their Premier League status.
Di Santo told The Wigan Observer: "We've given ourselves some breathing space at the bottom, but it's not over yet.
"Three wins would be enough, maybe less, but we don't want to let our standards slip now.
"The way we've played in recent weeks, and the teams we've beaten, we're good enough to finish with four wins."
The Argentine youth international was delighted to grab a goal against Arsenal on Monday night, taking his tally to five for the season, but he realises the three points are far more important.
"It was great to score but it's all about the three points - that's the only thing that matters," he added.
"The last two games have been amazing, but the most important thing is the points we've won and the way the league table looks now.
"We went to Arsenal to win, we knew it would be tough but we had enough confidence generated by the last 10 games to know we can match anyone.
"We believe in what we've been doing, we got off to the perfect start and fortunately we were able to see it through."