The Citizens are without their Spanish star for their trip to Arsenal, who themselves make just one change from their defeat at QPR last time out
The Spaniard is believed to have suffered a knock to his knee in training, but is expected to be back in time for Wednesday's clash with West Brom.
City manager Roberto Mancini makes five changes from the side which drew 3-3 at home with Sunderland last Saturday, as Pablo Zabaleta, Sergio Aguero and Gareth Barry return, and Samir Nasri and Gael Clichy prepare to face their former club.
Micah Richards, Nigel De Jong, Kolo Toure, Edin Dzeko and Aleksandar Kolarov drop out of the side.
Arsenal make just one change from their surprise defeat to QPR last Saturday, with Yossi Benayoun coming in for Aaron Ramsey.
Arsenal: Szczesny; Sagna, Vermaelen, Koscielny, Gibbs; Song, Arteta; Walcott, Rosicky, Benayoun; Van Persie
Subs: Santos, Oxlade-Chamberlain, Ramsey, Djourou, Fabianski, Jenkinson, Chamakh
Manchester City: Hart; Zabaleta, Kompany, Lescott, Clichy; Yaya Toure, Barry, Milner; Nasri, Aguero, Balotelli
Subs: Pantilimon, Richards, Pizarro, Dzeko, Kolarov, Tevez, De Jong