The Italian saw his side slump to a 1-0 defeat against Arsenal at the Emirates as Manchester United opened up an eight-point advantage at the top of the Premier League
A late Mikel Arteta strike consigned the Etihad Stadium outfit to a defeat at the Emirates to follow Manchester United's win at home to QPR, leaving the gap at the top at eight points in favour of Sir Alex Ferguson's champions.
However, although admitting that securing the club's first top division title since 1968 will now prove "difficult", Mancini is adamant that he can deliver for the club. When asked whether he is the man to bring the title to City, he replied: "Sure. One hundred per cent."
He continued: "After today the title is more difficult but you can play to win always and see at the end what happens.
"We have 15 points more than last year and we have done a fantastic season. I won one title [with Inter] when we were five points behind, five games from the end – this is football so we will see. Everything can happen but clearly we need to start to win.
"I am disappointed. Today we lost and didn’t do a good performance and for this I am disappointed but from tomorrow I will think about the next game."
Mancini was quick to point out the improvement made at City under his tenure, claiming that the club is in a far better position than when he replaced Mark Hughes as manager in December 2009 but admitting that his side need to improve.
"When I arrived at Manchester City we were in eighth or seventh then after six months we were fighting for the Champions League and we lost against Tottenham one game to the end," he said.
"A year later we were third position and we won the FA Cup and today we are 15 points more [than at this point last season].
"When you start a project it is important you improve. We were there [top of the table] for 28 games but we need to improve. We need more experience and we need to change something."
Despite refusing to concede defeat in the title race, Mancini praised Manchester United for their recent form and acknowledged that the club's experience of title chases in recent years is likely to play into their hands over the final weeks of the season.
"Manchester United have won 11 games and had one draw, they have done some incredible winning but in football it can change," he said. "They have more experience than us so probably it’s difficult."