The Belgian defender has missed City's last four matches with a calf injury he picked up in the first leg of their Europa League tie against Sporting Lisbon.
Fellow centre-back Joleon Lescott, however, is unlikely to return due to a groin problem.
"Joleon I don't think [will play against Stoke] but for Vinnie maybe he has some chance," Mancini told reporters.
Manchester City are 14/1 with Paddy Power to be winning at half-time and drawing at full-time in their meeting with Stoke on Saturday.
Mancini admitted after the Chelsea victory that City had not been at their best in recent weeks but hoped the dramatic win over the Blues could trigger an improvement in their form.
"I don't think that we played well in the last three or four weeks," Mancini conceded.
"I think at times we have played fantastic football but in the last month maybe it has been so-so.
"I think that after tonight maybe something can change."
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