The Black Cats were well beaten at the Hawthorns, but Cattermole is keen for his side to focus on the positives.
"It's been a tremendous last few months and we've got a lot to play for this season so we can't be too disheartened," he told the club’s official website.
"It's the first time we've been rolled over by a team. Nothing went our way on the day, we gave sloppy goals away and the players were really trying but just kept getting pulled all over the pitch."
Despite this he has backed the spirit within the squad to help them move on from the defeat.
"It's going to be a tough 48 hours but I think we'll come back and respond well. We've got a great set of lads in the dressing room and we'll bounce back."
Cattermole highlighted the goal conceded early in the second half as the killer blow on a poor afternoon for the Wearsiders.
"I think if we scored after the break we might have had a good chance, but to concede so soon after half-time, especially when we had most of the ball, was very sloppy.
"Everyone is extremely disappointed but we've just got to move on from it. It's the first time we've been beaten by more than one goal this season.
"This type of defeat will test the squad and see what we're all about, but I think we've got what it takes to bounce back."