The Mexico forward insists his side want to win the the competition despite being in Europe's second tier competition for the first time since 1995
The England striker spent last season on loan at fellow Premier League side Sunderland, impressing throughout his spell, despite picking up a lengthy injury and Hernandez is pleased is back at Old Trafford.
The Mexican also admitted the team need to get to grips with not playing in Europe's elite competition, the Champions League, but they plan on winning the Europa League purely because they are in it.
"The history of Manchester United is such that it doesn't matter which competition you are in, we want to win it, no matter who else is in it, or whether it is an important trophy for other teams," Hernandez said.
"We need to get used to the fact we are not in the Champions League this season."
The Red Devils, who face Ajax in the last 32 of the competition, could potentially find themselves pitted against bitter rivals Manchester City in the latter stages if they both progress far enough.
Chicharito, however, is focused on the job in hand and recognises the stature of Ajax, just one of the clubs they will have to overcome if they are to go on and lift the trophy.
"Both teams have come out of the Champions League and they both have a great history.
"We have won a lot of European Cups between us, so it will be a very interesting game."
Despite Hernandez's successful first season at Manchester United, the former Chivas man has suffered injury troubles this term as well as having to fight for his place in the team, but the striker insists he is still happy at Old Trafford despite Welbeck's emergence.
He went on: "It has been a little bit frustrating because I have been injured a lot.
"I am happy and I am still enjoying it. It is a privilege to play for Manchester United, whether things are going good or bad, I want to keep that attitude.
"Danny Welbeck is a brilliant player.
"He is only young but he went to Sunderland and did great things there. Then he came back here and has been unbelievable.
"That doesn't upset me, competition is normal at a club like this. You need to be at your best to help the team. That is the most important thing."