Patrice Evra and Luis Suarez go head-to-head at Old Trafford in the day's early game, while the Gunners face Martin O'Neill's rejuvenated side at the Stadium of Light
Our LIVE! service brings you team news, fan views, goal flashes, red cards and match reaction - all in one place.
With reporters around the grounds, we can bring the Premier League afternoon to life on your computer - from whether Patrice Evra and Luis Suarez shake hands at Old Trafford, to how Arsenal fare away to Sunderland.
Click on the link below and you can follow all the matches this afternoon, beginning with the 12:45 kick-off between Manchester United and Liverpool:
Six matches then get under way at 15:00, including Chelsea's trip to Everton, Sunderland's match against Arsenal, Blackburn Rovers' clash with QPR and Fulham's game against Stoke City.
Elsewhere, Bolton Wanderers take on Wigan Athletic and Swansea City face Norwich City, while Tottenham host Newcastle United in the day's evening kick-off.
With reaction coming in from around the country, Goal.com will bring you the best of what every manager and star player has to say on the games within moments of the final whistle.
No matter who you support, you'll get all the news and views you need right here throughout the afternoon.
How do you stay up to date with football when on the move? With http://m.goal.com – your best source for mobile coverage of the beautiful game.