The manager was set to make the trip from London City Airport after his court case but his flight has been cancelled due to what is believed to be a technical fault with the plane
Redknapp was due to make the trip from London City Airport following a day in court for his trial for tax evasion, but his flight has been cancelled due to what is being reported as a technical fault with the plane.
Assistant manager Kevin Bond and first-team coach Joe Jordan will take charge of the game at Anfield.
Bond told Sky Sports: "He was going to be here with plenty of time and then he was struggling and going to be here with not much time and I’m not really 100 per cent sure but it looks like he’s struggling.
"We knew what team we were going to play and how we were hoping to play so we’ve got that message across to the players. Hopefully not too much will change and it won’t make too much difference to us."
The news will come as a blow to Spurs fans after also hearing that Younes Kaboul would also miss the match through a knee injury, as well as continuing doubts over the fitness of key players such as Aaron Lennon, Rafael van der Vaart and Jermain Defoe.
One glimmer of cheer for the travelling away support is that an earlier referee's inspection at Anfield has rendered positive results, with the match due to go ahead despite heavy fog near the area.