Sir Alex Ferguson's side aim to close the gap on rivals Manchester City at the top of the table, while the Gunners have the chance to move into a Champions League spot
Our LIVE! service brings you team news, fan views, goal flashes, red cards and match reaction - all in one place.
With reporters around the grounds, we bring the Premier League afternoon to life on your computer - from whether Manchester United can bounce back from their midweek defeat to Basel with a win over Wolves, to how Arsenal fare against Everton at the Emirates Stadium.
Click on the link below and you can follow all the matches this afternoon:
With no early or late kick-offs, a further five matches take place at 15:00, including Liverpool's clash with QPR and Newcastle United's trip to Norwich City.
Elsewhere, Bolton Wanderers face Aston Villa, Fulham travel to Swansea City and West Brom host Wigan Athletic.
With reaction coming in from around the country, Goal.com will bring you the best of what every manager and star player has to say on the games within moments of the final whistle.
No matter who you support, you'll get all the news and views you need right here throughout the afternoon.